Job summary
Applications are invited from State Registered Clinical Scientists in Genomics. Scientists close to registration will also be considered.
You will be joining the team at the North Thames Rare Disease Genomics Laboratory at Great Ormond Street Hospital. We are seeking enthusiastic, self-motivated Scientists with experience of clinical genomics service delivery and a sound understanding of genomic techniques including variant assessment. Accomplished communication and organisational skills are required.
You will support an area of our core, specialist or prenatal genomics service dependent on experience. Applications are welcome from registered scientists from either cytogenetics or molecular genetics. Our scientific teams are cross-discipline with opportunities for cytogenetics and molecular genetics across the department. We support trained scientists who wish to adopt flexible and/or partially remote working patterns.
Main duties of the job
The GOSH Genomics Laboratory has an establishment of approximately 180 including Technologists, Clinical Scientists, Translational Scientists, Bioinformaticians and Administrative Support staff. Along with two Clinical Genetics Teams we form a strategic Genetics Unit within the hospital and provide North London with a Regional Genetics Service serving a population of approximately 10 million. The laboratory provides an in-house diagnostic service for paediatric and inherited cancer, molecular and cytogenetic testing in accordance with the NHS England Genomic Test Directory; this includes services for 11 of the designated specialist areas for the NHSE Genomic Medicine Service. Genomic testing is provided for both prenatal and postnatal samples using SNP microarray, karyotyping, FISH, qPCR, MLPA, Next generation sequencing, rapid genome sequencing, and various targeted tests. We are also engaged in the delivery of the NHSE GMS Whole Genome Sequencing programme for our North Thames patients.
We are involved in a number of collaborative research and development projects with colleagues at the UCL Institute of Child Health and Institute of Neurology as part of the UCL Partners Academic Health Sciences Centre. We host a team of Translational and Research Scientists focusing on translation of new genomic technologies to the diagnostic service.
About us
We are committed to recruiting the best person for the job through a fair, open and consistent process that is free from bias and discrimination.
We are working towards becoming an anti-racist organisation. This means creating a workplace where every colleague feels seen, heard and valued, and where racism in any form has no place. Our anti-racism commitment is backed by action through our Anti-Racism Statement and action plan, developed in collaboration with our REACH staff network.
We actively challenge discrimination, dismantle barriers and embed equity across all aspects of our workforce, including recruitment, progression and development. All applicants will receive equal consideration regardless of race, ethnicity, nationality, religion or belief, sexual orientation, gender identity, age, disability, health condition or employment history.
We particularly welcome applications from ethnically diverse communities, people with disabilities or long-term health conditions, and LGBTQ+ community members. We are proud to be a Disability Confident Employer, a member of the Business Disability Forum, and a Stonewall Diversity Champion.
Our staff networks, including REACH, PRIDE, ENABLED and Women's Networks, are active and executive supported. These employee-led networks play a vital role in shaping an inclusive culture at GOSH and are open to all colleagues.
Together, we are building a culture where inclusion is not optional - it is essential.
Job description
Job responsibilities
The full job description provides an overview of the key tasks and responsibilities of the role, and the person specification outlines the qualifications, skills, experience and knowledge required. For both documents please view the attachment/s below.
Person Specification
Combined Values
Essential
- Combined Values
Academic/Professional qualification/Training
Essential
- First or Second Class Degree in Molecular Biology, Genetics, Biochemistry or related subject
- HCPC Clinical Scientist Registration Certificate
Desirable
- Postgraduate qualification in Genomics
Experience/Knowledge
Essential
- Extensive knowledge of clinical genomics and a demonstrable track record in the delivery of a diagnostic service
- Knowledge of structural chromosome rearrangements and segregation, CNV analytical methods and clinical applications OR
- Knowledge and experience of molecular variant classification in accordance with ACGS guidance and their application for all modes of inheritance
- Track record of scientific Publications/ presentations
- Significant postgraduate experience in a clinical genomics laboratory
Desirable
- Evidence of supervising/training other staff
- Experience with laboratory information and quality management systems
Skills/Abilities
Essential
- Skilled in the use and application of molecular genetics and/or cytogenetic techniques
- Skilled in genomic CNV analysis by use of G banded chromosomes / FISH / Microarray OR Skilled in Next Generation Sequencing Applications / Sanger Sequencing / Dosage analysis
- Able to establish and validate new techniques / tests including ability to troubleshoot. Willing to adapt to changes in methodology
- Computer literate, including use of DNA/Genetic databases, analytical software, variant classification
- Able to communicate effectively both verbally and in writing (by email and by appropriate documentation)
- Able to write protocols
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Certificate of Sponsorship
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).
UK Registration
Applicants must have current UK professional registration. For further information please see NHS Careers website (opens in a new window).
Employer details
Employer name
Great Ormond Street Hospital for Children NHS Foundation Trust
Address
Great Ormond Street Hospital for Children
London
WC1N 3JH
United Kingdom
Employer's website
This listing was aggregated from publicly-available sources. The employer holds an A-rated sponsor licence at the time of this listing, but sponsorship of this specific role is not guaranteed — the employer's offer and UK Visas and Immigration are the final authority. Details may have changed since our last update — verify with the employer via the Apply link.